The forthcoming book, “Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging” by Professors Albert Reece and Gary Hulse, is not only a cornerstone in the study of cannabis-related health impacts, but a must have for any clinician, researcher or health-care practitioner. Set to release on March 1, 2025, this comprehensive volume explores four critical areas associated with cannabis use: mental health issues, paediatric autism, congenital anomalies, and cancer.

Section 1: Advanced Analytical Techniques and Population Health

The authors, both esteemed figures in their fields, leverage cutting-edge analytical software and geospatial space-time techniques to explore how these health issues manifest at the population level. Their work highlights the intricate associations between cannabis use and mental health deterioration, presenting geospatiotemporal studies at national, regional, state, and sub-state levels.

Section 2: Cannabis and Autism: A Detailed Examination

The book meticulously examines the parallel rise in cannabis use and autism incidence, providing a nuanced understanding of legal status and autism trends through detailed geospatial analysis. This section offers crucial insights into how societal changes influence health trends and conditions.

Section 3: Congenital Anomalies: Historical Parallels and Modern Implications

In exploring congenital anomalies, the book presents a geotemporospatial analysis of multiple cannabinoid exposures during cannabis legalisation periods. This in-depth exploration draws parallels with historical health crises like thalidomide, emphasising the genotoxic potential of cannabis.

Section 4: The Cancer Connection: Heritable Genotoxicity

The section on cancer scrutinises heritable cannabis-related genotoxicity and its reflections in rising cancer rates across various demographic groups in the USA. It provides an in-depth look at how cannabis use might affect genetic health over generations.

Section 5: The Role of Epigenetics and Aging

The exploration of epigenetics and ageing adds another layer of depth to the book. It provides insights into how cannabis-related epigenetic changes can influence teratological, carcinogenic, and age-accelerated diseases, offering a detailed account of recent findings in the field.

This extensive research is a vital resource for clinicians, public health practitioners, and researchers aiming to understand the complex health impacts of cannabis. It is also a valuable addition to educational curricula at both undergraduate and postgraduate levels, fostering a deeper comprehension of addiction medicine, genetics, and neurology.

Authors’ Expertise and Contributions

The authors bring a wealth of academic, but more importantly in the field experience to this work. Dr. Albert Stuart Reece, a seasoned medical practitioner, has extensive experience in addiction medicine and holds surgical fellowships and a Doctorate of Medicine in liver transplantation. Professor Gary Kenneth Hulse has dedicated over 30 years to alcohol and drug use research, contributing significantly to medical education in this field. Their combined expertise ensures this compendium is both a rigorous academic study and a practical guide for those engaged in health science and policy.

As cannabis legalisation progresses worldwide, this outstanding research offers crucial insights into potential public health implications, serving as an invaluable resource for policymakers, healthcare professionals, educators, researchers, and all stakeholders involved in managing the complexities of cannabis-related impacts.

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