Nitazenes, 40 Times Stronger Than Fentanyl

Nitazenes, 40 Times Stronger Than Fentanyl

In a recent revelation that underscores the evolving challenges in the battle against drug abuse, a new class of synthetic opioids known as nitazenes has emerged, reportedly up to 40 times more potent than fentanyl. This information comes from a detailed examination by OregonLive, which sheds light on the substance’s deadly potential and its growing presence on the streets.

Historical Origins and Resurgence of Nitazenes as Illegal Street Drugs

Nitazenes, encompassing over 20 unique compounds including isotonitazene (ISO), were originally developed in the 1950s for pain relief by the Swiss chemical company CIBA but never gained approval for medical use. Despite this, these substances have reappeared as illegal street drugs, with their potency posing unprecedented risks. The Drug Enforcement Agency (DEA) has classified many nitazenes as Schedule I drugs, indicating their high potential for abuse and lack of accepted medical use.

The resurgence of nitazenes as a public health threat is largely attributed to the crackdown on other opioids like fentanyl. Illegal laboratories have turned to historical pharmacology research to create analogs of nitazenes, leading to at least 200 drug-related overdose deaths in Europe and the United States since their reemergence in 2019. These drugs have been found in various forms, from white powdery substances resembling cocaine to blue tablets, often mixed unknowingly with other street drugs, increasing the risk of overdose.

The Difficulty in Detecting and Treating Nitazene-Related Overdoses

Adding to the complexity, specialised lab testing is required to identify nitazenes, as conventional fentanyl test strips cannot detect them. This has made it difficult for medical providers and law enforcement to keep pace with the spread of these drugs. The toxic effects of nitazenes, including respiratory and central nervous system depression, can lead to rapid death, making timely medical intervention crucial. Fortunately, naloxone (Narcan) has been effective in reversing overdoses, although higher or multiple doses may be necessary due to the potency of nitazenes.

This alarming development calls for increased awareness among healthcare providers, law enforcement, and the public about the dangers of nitazenes. With the opioid crisis already straining public health resources, the emergence of a drug far surpassing fentanyl in potency is a stark reminder of the ongoing battle against drug abuse and the necessity for comprehensive strategies to address this menace.

For more insights into this pressing issue, read the full article on OregonLive.

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